Submit Manuscript  

Article Details


Scorpion Toxins Targeting Voltage-gated Sodium Channels Associated with Pain

[ Vol. 19 , Issue. 11 ]

Author(s):

Yijia Xu, Junxin Sun, Hongyu Liu, Jianfang Sun, Yue Yu, Yang Su, Yong Cui, Mingyi Zhao* and Jinghai Zhang*   Pages 848 - 855 ( 8 )

Abstract:


Pain affects approximately 30% of people and places a large economic and social burden on society. Despite the availability of a range of analgesics, complete alleviation of symptoms still rarely occurred. Effective and safe drugs for the treatment of pain are still an unmet clinical need. In recent years, the voltage-gated sodium channels (VGSCs) have been recognized as potential targets for analgesic development. VGSCs are major players in generating and propagating action potentials. They represent an appealing target for the development of new and safer drugs in the treatment of pain. The majority of the research has been focused on Nav1.7 in particular, other VGSC subtypes, such as Nav1.1, Nav1.3, Nav1.6, Nav1.8 and Nav1.9 have recently come to the forefront of analgesic research. Peptides from scorpion have been proved to be a valuable tool in neuroscience, playing a significant role in the identification and characterization of VGSC subtypes and many of them resulting in analgesia in pain. This review assesses the potential of scorpion toxin targeting VGSCs for analgesic development.

Keywords:

Pain, VGSC, peptide, scorpion toxin, autoimmune diseases, NSAIDs.

Affiliation:

School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, CN, School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, CN, School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, CN, College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, 110004, CN, College of traditional Chinese medicine, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, CN, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, CN, School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, CN, School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, CN, School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, CN



Read Full-Text article