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Evaluation of Changes in the Expression Pattern of EDIL3 in Different Grades of Endometrial Cancer

[ Vol. 20 , Issue. 6 ]

Author(s):

Marcin Oplawski*, Konrad Dziobek, Nikola Zmarzły, Beniamin Grabarek, Barbara Tomala, Ewa Leśniak, Iwona Adwent, Piotr Januszyk, Dariusz Dąbruś and Dariusz Boroń   Pages 483 - 488 ( 6 )

Abstract:


Background: EDIL3 is an extracellular matrix protein that plays a key role in angiogenesis. Changes in the pattern of its expression also affect cellular processes and the tumor microenvironment. Elevated level of EDIL3 is considered an unfavorable prognostic marker of survival.

Objective: The aim of this study was to evaluate the changes in EDIL3 expression in endometrial cancer at various degrees of its differentiation (G1-G3) and to discuss its potential role as a molecular diagnostic marker and therapeutic target.

Methods: The study group consisted of 45 patients with endometrial cancer: G1, 17; G2, 15; G3, 13. The control group (C) included 15 patients without neoplastic changes. The expression of EDIL3 was assessed using immunohistochemistry. Statistical analysis was performed using the Statistica 12 PL software (p<0.05).

Results: Analysis of EDIL3 expression showed that the average optical density of the reaction product in G1 reached 130% of the control, while the values in G2 and G3 were 153% and 158%, respectively. Regardless of the endometrial cancer grade, an increase in EDIL3 level was observed compared to the control.

Conclusion: In our study, we demonstrated overexpression of EDIL3 protein in endometrial cancer. Differences in expression between degrees of tumor differentiation suggest the potential of using changes in EDIL3 level as a new complementary diagnostic marker and target for anti-angiogenic therapy.

Keywords:

EDIL3, endometrial cancer, complementary diagnostic marker, immunohistochemistry, personalized medicine, epithelial-mesenchymal transition, TGFβs.

Affiliation:

Department of Gynecology and Obstetrics with Gynecologic Oncology, Ludwik Rydygier Memorial Specialized Hospital, Krakow, Center of Oncology, M. Sklodowska-Curie Memorial Institute, Cracow Branch, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Faculty of Health Science, Public Higher Medical Professional School in Opole, Faculty of Health Science, Public Higher Medical Professional School in Opole, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Faculty of Health Science, Public Higher Medical Professional School in Opole, Faculty of Health Science, Public Higher Medical Professional School in Opole

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