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Recent Insights into Effective Nanomaterials and Biomacromolecules Conjugation in Advanced Drug Targeting

[ Vol. 20 , Issue. 7 ]

Author(s):

Abbas H. Azandaryani , Soheila Kashanian * and Tahereh J. Tosaramandani   Pages 526 - 541 ( 16 )

Abstract:


Targeted drug delivery, also known as smart drug delivery or active drug delivery, is a subcategory of nanomedicine. Using this strategy, the medication is delivered into the infected organs in the patient’s body or to the targeted sites inside the cells. In order to improve therapeutic efficiency and pharmacokinetic characteristics of the active pharmaceutical agents, conjugation of biomacromolecules such as proteins, nucleic acids, monoclonal antibodies, aptamers and so on to nanoparticulate drug carriers has been mostly recommended by scientists in the last decades. Several covalent conjugation pathways are used for biomacromolecules coupling with nanomaterials in nanomedicine including carbodiimides and “click” mediated reactions, thiol-mediated conjugation, and biotin-avidin interactions. However, choosing one or a combination of these methods with suitable coupling for application to advanced drug delivery is essential. This review focused on new and high impacted published articles in the field of nanoparticles and biomacromolecules coupling studies, as well as their advantages and applications.

Keywords:

Nanobiotechnology, biomacromolecule, targeted drug delivery, nanomedicine, chemical coupling, “click” mediated reactions, carbodiimides, thiol-mediated conjugation, biotin-avidin.

Affiliation:

Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah, Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah, Faculty of Science, Razi University, Kermanshah



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