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Antibacterial and Potential Antidiabetic Activities of Flavone C-glycosides Isolated from Beta vulgaris Subspecies cicla L. var. Flavescens (Amaranthaceae) Cultivated in Egypt

[ Vol. 20 , Issue. 7 ]

Author(s):

Hala Sh. Mohammed, Marwa M. Abdel-Aziz, Marwa S. Abu-Baker, Amal M. Saad, Mona A. Mohamed and Mosad A. Ghareeb   Pages 595 - 604 ( 10 )

Abstract:


Background: Infectious diseases and diabetes mellitus are very important issues. In this context, Beta vulgaris cicla L. var. flavescens is a leafy green vegetable that has been widely used in traditional medicine for the treatment of various health disorders.

Objective: The current study was performed to evaluate the antimicrobial and anti-diabetic potential of different extracts and isolated flavone C- glycoside compounds from Beta vulgaris subspecies cicla L. var. flavescens leaves.

Methods: Characterization of flavone C-glycosides isolated from n-butanol extract of Beta vulgaris subspecies cicla L. was carried out via using spectroscopic tools including 1D-NMR (1HNMR, 13C NMR), 2D-NMR (1H-1H-COSY, HMQC & HMBC) and comparison with literature. The isolated compounds were screened in vitro for their antibacterial activity against some human bacterial pathogens (which represent prominent human pathogens, particularly in hospital settings) viz.; Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Proteus mirabilis, Proteus vulgaris, Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella typhi. Also, were screened for their antidiabetic activity using α-glucosidase inhibitory assay.

Results: Five flavone C-glycosides namely; Vitexin (1), Vitexin (1'''-2'')-O-xylopyranoside (2), Acacetin 8-C-β-D-glucopyranoside (3), Acacetin 8-C-α-L-rhamnoside (4), and 6,8-di-C-β-D-glucopyranosyl- apigenin (Vecinin-II) (5) were isolated from Beta vulgaris L. Compound (1); showed antibacterial potential against Gram-positive and Gram-negative bacteria with minimum inhibitory concentrations range 15.63-1.95µg ml-1. On the other hand, compounds (1 & 3) showed superior in antidiabetic activity with IC50 35.7 and 42.64 µg ml-1 respectively, while the other compounds are inferior in antidiabetic activity.

Conclusion: B. vulgaris is a potential candidate for the treatment of several health disorders associated with infectious diseases and diabetes.

Keywords:

Amaranthaceae, Beta vulgaris subspecies cicla L. var. flavescens, flavonoids, antibacterial, antidiabetic.

Affiliation:

Department of Pharmacognosy, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, The Regional Center for Mycology and Biotechnology, Al-Azhar University, Cairo, Department of Pharmacognosy, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, Warrak El-Hadar, Imbaba (P.O. 30), Giza 12411, Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, Warrak El-Hadar, Imbaba (P.O. 30), Giza 12411, Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, Warrak El-Hadar, Imbaba (P.O. 30), Giza 12411



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