Girish M. Bhopale* Pages 90 - 96 ( 7 )
Antimicrobial drugs resistant microbes have been observed worldwide and therefore alternative development of antimicrobial peptides has gained interest in human healthcare. Enormous progress has been made in the development of antimicrobial peptide during the last decade due to major advantages of AMPs such as broad-spectrum activity and low levels of induced resistance over the current antimicrobial agents. This review briefly provides various categories of AMP, their physicochemical properties and mechanism of action which governs their penetration into microbial cell. Further, the recent information on current status of antimicrobial peptide development, their applications and perspective in human healthcare are also described.
Antimicrobial peptides, antimicrobial peptide development, therapeutic agents, antimicrobial resistance, synthetic antimicrobial peptide, drug resistant bacteria.
Microbial Diversity Research Centre, Dr. D.Y. Patil Biotechnology & Bioinformatics Institute, Dr. D.Y. Patil Vidhyapeeth, Tathawade, Pune, 411033, M.S