Yong Zhang, Qiuyan Weng, Jianming Chen and Jinming Han* Pages 1402 - 1409 ( 8 )
Objective: Osteosarcoma is considered as one of the most common types of bone tumors, which occurs among adolescents and children.Methods: Current therapy strategies still have limited effectiveness therefore, the development of new therapies is urgent. Morusin is a compound isolated from Morus australis (Moraceae). Many studies have reported its anti-tumor effect on several tumor types. However, its role in osteosarcoma is still unclear. Results: In this study, we determined that morusin significantly suppresses the proliferation and promotes the apoptosis of osteosarcoma cells. Furthermore, the migration and invasion of osteosarcoma were reduced after exposure to morusin. The deep mechanism was determined to be the inhibition of the PI3K/AKT signaling pathway. Conclusion: In conclusion, our study indicates morusin as a potential candidate for osteosarcoma therapy.
Morusin, osteosarcoma, PI3K/AKT, therapy, MMPs, human osteosarcoma.
Departments of Trauma Orthopedics, Ningbo No 6 Hospital, Ningbo 315000, Zhejiang, Departments of Neurology, The Affiliated Hospital of the Medical School of Ningbo University, 315000, Zhejiang, Departments of Trauma Orthopedics, Ningbo No 6 Hospital, Ningbo 315000, Zhejiang, Departments of Spine, Ningbo No 6 Hospital, Ningbo 315000, Zhejiang