Oleophylic Nanospheres Self-Assembly by Emulsion Technique Utilizing the Automatic Nanoscalar Interfacial Alternation (ANIAE)

Author(s):

Hao Ran, Weibin Liu*, Xin Pan*, Chuanbin Wu*, Guilan Quan, Ying Huang and Yingtong Cui   Pages 182 - 190 ( 9 )

Abstract:

Background: The administration of many pharmaceutical active ingredients is often performed by the injection of an aqueous-based solution. Numerous active ingredients are however, insoluble in water, which complicates their administration and restricts their efficacy.

Objective: The current solutions are hindered by both, a time-consuming manufacturing process and unsuitability for hydrophilic and hydrophobic materials.

Methods: Emulsions of oleophilic active ingredients and polyprotein microspheres are an important step to overcome insolubility issues.

Results: Polyprotein microspheres offer a versatile modifiable morphology, thermal responsivity, and size variation, which allows for the protection and release of assembled biomaterials. In addition, nanospheres present promising cell phagocytosis outcomes in vivo.

Conclusion: In this research, a reproducible multifunctional approach, to assemble nanospheres in one step, using a technique termed “automatic nanoscalar interfacial alternation in emulsion” (ANIAE) was developed, incorporating a thermally controlled release mechanism for the assembled target active ingredients. These results demonstrate a viable, universal, multifunctional principal for the pharmaceutical industry.

Keywords:

Self-Assembly, oleophilic nanospheres, polyprotein, ANIAE, thermally controlled release, assembled biomaterials.

Affiliation:

School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, Department of Neurology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006

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