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Article Details


Combinatorial Protein Biochemistry for Therapeutics and Proteomics

[ Vol. 5 , Issue. 1 ]

Author(s):

David Lowe and Lutz Jermutus   Pages 17 - 27 ( 11 )

Abstract:


This paper reviews progress towards the customised generation of proteins for applications as therapeutics, diagnostics and in proteomics. It particularly focuses on combinatorial approaches where proteins with pre-defined biochemical and biophysical characteristics are selected from large variant libraries.

Keywords:

protein therapeutic, protein engineering, display, directed evolution, alternative frameworks

Affiliation:

Cambridge Antibody Technology, Milstein Building, Granta Park, Cambridge CB1 6GH, UnitedKingdom.



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