David Lowe and Lutz Jermutus Pages 17 - 27 ( 11 )
This paper reviews progress towards the customised generation of proteins for applications as therapeutics, diagnostics and in proteomics. It particularly focuses on combinatorial approaches where proteins with pre-defined biochemical and biophysical characteristics are selected from large variant libraries.
protein therapeutic, protein engineering, display, directed evolution, alternative frameworks
Cambridge Antibody Technology, Milstein Building, Granta Park, Cambridge CB1 6GH, UnitedKingdom.