Submit Manuscript  

Article Details

Combinatorial Protein Biochemistry for Therapeutics and Proteomics

[ Vol. 5 , Issue. 1 ]


David Lowe and Lutz Jermutus   Pages 17 - 27 ( 11 )


This paper reviews progress towards the customised generation of proteins for applications as therapeutics, diagnostics and in proteomics. It particularly focuses on combinatorial approaches where proteins with pre-defined biochemical and biophysical characteristics are selected from large variant libraries.


protein therapeutic, protein engineering, display, directed evolution, alternative frameworks


Cambridge Antibody Technology, Milstein Building, Granta Park, Cambridge CB1 6GH, UnitedKingdom.

Read Full-Text article