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Single-Molecule Protein Interaction Conformational Dynamics

[ Vol. 10 , Issue. 5 ]

Author(s):

H. Peter Lu   Pages 522 - 531 ( 10 )

Abstract:


Protein conformational fluctuations and dynamics, often associated with static and dynamic inhomogeneities, play a crucial role in biomolecular functions. It is extremely difficult to characterize such spatially and temporally inhomogeneous dynamics in an ensemble-averaged measurement, especially when the proteins involve in a multiple-step and multiple-conformation complex chemical interactions and transformations, such as in protein-protein interactions and protein- DNA interactions. Single-molecule spectroscopy is a powerful approach to analyze protein conformational dynamics under physiological conditions, providing dynamic perspectives on a molecular-level understanding of protein structurefunction mechanisms.

, Single-Molecule, Protein, Interaction, Conformational, Dynamics

Affiliation:

Department of Chemistry, Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA.



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