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HIV-Tuberculous Meningitis Co-Infection: A Systematic Review and Meta-Analysis

[ Vol. 22 , Issue. 7 ]

Author(s):

Ali Purmohamad, Taher Azimi, Mohammad J. Nasiri, Mehdi Goudarzi, Moein Zangiabadian, Hamid Sedighian and Abbas A.I. Fooladi*   Pages 960 - 968 ( 9 )

Abstract:


Human Immunodeficiency Virus (HIV)-infected persons are at a higher risk of developing Tuberculous Meningitis (TBM). We aimed to estimate the prevalence of TBM-HIV co-infection. We systematically searched Pubmed/Medline, Embase and Cochrane library databases from January 1, 2000, to January 31, 2017, to find relevant studies. We employed the random-effects meta-analysis model to estimate the pooled prevalence of TBM-HIV co-infection. Twenty-six eligible studies showed the prevalence of HIV in TBM patients. In the pooled analyses, the prevalence of HIV was 30% (95% CI: 12-47) in patients with confirmed TBM, and 12.1% (95% CI: 7.3-19.2) in patients with suspected TBM. This study shows a high prevalence of TBM-HIV co-infection. Establishing proper diagnostic criteria and preventive measures for TBM infections could assist in the prevention and management of TBM infection, particularly TBM-HIV co-infection.

Keywords:

Meta-analysis, HIV, meningitis, Mycobacterium tuberculosis, TBM, prevention.

Affiliation:

Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran

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